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Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Amaropostia stiptica were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Cerrena unicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomes fomentarius were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitiporia punctata were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Fomitopsis pinicola were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Grifola frondosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Irpex lacteus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Laetiporus sulphureus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Lentinus brumalis were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Neolentinus lepideus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Perenniporia fraxinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Phlebiopsis gigantea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Poriella subacida were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Steccherinum sp. were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes coccinea were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes gibbosa were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes hirsuta were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes pubescens were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametes versicolor were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trametopsis cervina were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Trichaptum abietinum were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Apigenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Baicalin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Catechin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Daidzein dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Honokiol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Kaempferol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Magnolol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Naringenin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Quercetin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Resveratrol dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Agar plugs (5 mm) of the Xylodon flaviporus were inoculated into 200 mL of potato dextrose broth (PDB) medium in 500 mL Erlenmeyer flasks and incubated at 27℃ in a shaking incubator at 130 rpm. After 7 days, 10 mL of fermentation broth and mycelium was separated into a conical tube. Wogonin dissolved in DMSO were added into each tube to a final concentration of 10 mM, then maintained for 5 days under the same conditions. After 5 days, fermentation broths were extracted with an equal volume of ethyl acetate (EtOAc). Then, 2 mL of each EtOAc extract was dried in a vacuum, before being dissolved in 1 mL of 50 % methanol (MeOH) filtered through a PTFE syringe filter and injected into the LC-MS. , Apigenin dissolved in 50% MeOH (0.01mg/ml) , Baicalein dissolved in 50% MeOH (0.01mg/ml) , Baicalin dissolved in 50% MeOH (0.01mg/ml) , Catechin dissolved in 50% MeOH (0.01mg/ml) , Daidzein dissolved in 50% MeOH (0.01mg/ml) , Honokiol dissolved in 50% MeOH (0.01mg/ml) , Kaempferol dissolved in 50% MeOH (0.01mg/ml) , Magnolol dissolved in 50% MeOH (0.01mg/ml) , Naringenin dissolved in 50% MeOH (0.01mg/ml) , Quercetin dissolved in 50% MeOH (0.01mg/ml) , Resveratrol dissolved in 50% MeOH (0.01mg/ml) , Wogonin dissolved in 50% MeOH (0.01mg/ml) , 50% MeOH , QC samples; Mixed all used phytochemicals LC samples (apigenin, baicalein, baicalin, catechin, daidzein, honokiol, kaempferol, magnolol, naringenin, quercetin, resveratrol and wogonin) 100 ul, respectively

LC separations were carried out on an Acquity UPLC BEH C18 column (2.1 x 100 mm, 1.7 µm). Column temperature and flow rate were set to 40 °C and 0.3 ml/min, respectively. The mobile phases used were 0.1 % formic acid in water (A) and acetonitrile (B). The linear gradients were as follows: 10–100% B for 12 min followed by a 3 min washout phase at 100 % B and a 3 min re-equilibration phase at 10 % B, successively. The injection volume of the sample was set to 2.0 μl.

LC-MS/MS data used in this study were acquired using a Waters Acquity UPLC system (Waters Co., Milford, MA, USA) coupled to a Waters VION IMS Q/TOF mass spectrometer (Waters MS Technologies, Manchester, UK) equipped with an electrospray ionization (ESI) interface. MS/MS analyses were performed in MSE data-independent acquisition mode for negative ions.