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Experiment

KAE24062567

Experiment Title

Illumina NovaSeq 6000 paired-end Sequencing of PDAC35_PDX

This study aims to demonstrate the genomic discrepancies between pancreatic ductal adenocarcinoma (PDAC) patient tissues and model tissues during the establishment of patient-derived xenograft (PDX). We conducted whole exome sequencing and RNA sequencing on tissue samples from PDAC patients and their corresponding PDX tissues. As a result, we identified genetic alterations accumulated during PDX establishment and defined PDX model specific subtypes based on changes in gene expression profiles. This study is expected to enhance the utility of PDX models in achieving precision medicine for PDAC.

Common Fields

Common Fields - BioProject, Strategy, Source, Selection, Layout, Instrument, Submission date, Experiments
Organism	Homo sapiens \| 9606
Submission date	2024-03-21

Accession

Accession - RUNs, BIOSAMPLEs
Runs	All runs [171]
Experiments	All experiments [171]
BioSamples	All samples [105]
BioProject	KAP240672

Library

Common Fields - BioProject, Strategy, Source, Selection, Layout, Instrument, Submission date, Experiments
Library name	PDAC35_PDX_Exome-Seq
Instrument model	Illumina NovaSeq 6000
Strategy	WXS
Source	GENOMIC
Selection	CAGE
Layout	paired
Construction protocol	Library were generated using the SureSelect XT Human All Exon kit (Agilent Technologies Inc., CA, USA) from DNA extracted from samples.

The KRA run(s) below contain human sequence

These data are available through the KHBDB authorized access system.

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file 선택	Run	File Name	Size	Type	Published	Download
	KRA: KAR24062567	PDAC35_PDX_R1.fastq.gz	3,472,669,020 3,472,669,020	fastq	2024-03-20
	KRA: KAR24062567	PDAC35_PDX_R2.fastq.gz	3,644,847,588 3,644,847,588	fastq	2024-03-20

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