BioProject
KAP242359
BioProject Title
Reprograming of tumour-derived extracellular vesicles using nano-PROTACs (EVOTAC)
Common Fields
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BioProject
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KAP242359 |
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Taxonomic type
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Organism
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Mus musculus
(10090)
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Biomaterial provider
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American Type Culture Collection (ATCC)
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Submission date
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2026-05-07 |
Accession
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Experiments
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BioSample [Model organism or animal]
Showing of 1-20 of 29 cases
| BioSample ID | Identifier | Sample name | Age | Biomaterial provider | Birth date | Birth location | Breed | Breeding history | Breeding method | Cell line | Cell subtype | Cell type | Collected by | Collection Date | Cultivar | Culture collection | Death Date | Derived from | Description | Development stage | Disease | Disease stage | Ecotype | Genotype | Geographic location | Growth protocol | Health state | Isolate | Isolation source | Latitude and longitude | NCBI taxonomy ID | Organism | Phenotype | Sample type | Sex | Specimen voucher | Storage conditions | Strain | Stud book number | Tissue | Treatment | Other characteristics | Registration Date |
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| KAS24200427 | TAC7 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_07 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200426 | TAC6 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_06 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200425 | TAC5 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_05 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200424 | TAC4 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_04 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200423 | TAC3 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_03 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200422 | TAC2 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_02 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200421 | TAC1 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues following EVOTAC-treated and laser-irradiated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | EVOTAC_Laser_01 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC intravenous injection followed by laser irradiation | 2026-05-07 | |||||
| KAS24200420 | UN7 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_07 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200419 | UN6 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_06 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200418 | UN5 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_05 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200417 | UN4 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_04 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200416 | UN3 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_03 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200415 | UN2 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_02 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200414 | UN1 | 6 weeks | American Type Culture Collection (ATCC) | Orient Bio | BALB/c | Not collected | Not collected | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2026-02-13 | Not applicable | 2026-02-11 | Tumor-derived extracellular vesicles | Exosomal RNA isolated from EVs secreted by 4T1 tumor tissues of saline-treated BALB/c mice | Adult | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were orthotopically implanted into the mammary fat pad of BALB/c mice. | Diseased | Saline_01 | Orthotopic 4T1 mammary tumor tissue from BALB/c mice | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Tissue sample | female | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | Saline intravenous injection | 2026-05-07 | |||||
| KAS24200413 | VL5 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following VPF treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO16. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | VPF (+Laser) | 2026-05-07 | ||||||
| KAS24200412 | VL4 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following VPF treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO15. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | VPF (+Laser) | 2026-05-07 | ||||||
| KAS24200411 | VL3 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following VPF treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO14. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | VPF (+Laser) | 2026-05-07 | ||||||
| KAS24200410 | VL2 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following VPF treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO13. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | VPF (+Laser) | 2026-05-07 | ||||||
| KAS24200409 | VL1 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following VPF treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO12. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | VPF (+Laser) | 2026-05-07 | ||||||
| KAS24200408 | PL5 | Not applicable | American Type Culture Collection (ATCC) | Not applicable | Not applicable | Not applicable | Not applicable | 4T1 | Triple-Negative Breast Cancer | Murine mammary carcinoma epithelial cell | Korea Institute of Science and Technology (KIST) | 2025-05-15 | Not applicable | Extracellular vesicles derived from 4T1 cells | Exosomal RNA isolated from EVs secreted by 4T1 cells following EVOTAC treatment and laser irradiation | Not applicable | mammary carcinoma | Stage IV | Not applicable | Wild type | South Korea: Seoul | 4T1 cells were cultured in RPMI-1640 medium supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin at 37°C in a humidified atmosphere containing 5% CO11. | Diseased | Not applicable | Cultured 4T1 mouse mammary carcinoma cells | 10090 | Mus musculus | highly metastatic breast cancer phenotype | Cell culture | not applicable | ATCC:CRL-2539 | Not applicable | BALB/c | Not applicable | mammary gland tumor | EVOTAC (+Laser) | 2026-05-07 |