합성 유전자 서열
Synthetic construct for SARS-CoV-2 Omicron Spike Antigen using SARS-CoV-2, Omicron variant (BA.4/BA.5), sequence
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AccessionKSYN010000000003
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Submission date2025-08-22
Project Detail
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BioProject
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KAP241583 |
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프로젝트의 영문 제목
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Development of novel mRNA vaccine platform
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프로젝트의 영문 설명
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This project aimed to establish a novel mRNA vaccine platform to prepare for emerging and re-emerging viral diseases. Cap-dependent and circular mRNA platforms were developed and validated using reporter genes and vaccine antigens such as influenza HA and Disease X. In addition, an AI-based mRNA design platform was constructed, and LNP formulations were optimized to enhance expression and immune responses. The mRNA sequences generated through this project can serve as potential vaccine candidates for infectious disease preparedness and contribute to securing an independent national mRNA vaccine technology platform.
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등록자의 영문 이름
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Nam Jae-Hwan
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DataSet
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Name of submitter's organization
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The Catholic University of Korea
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Department of submitter
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Department of Medical and Biological Sciences
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Country of submitter
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South Korea
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Street address
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43 Jibong-ro
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City
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Wonmi-gu, Bucheon-si
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State / Province / Region
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Gyeonggi-do
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Zip Code (Postal Code)
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14662
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Contact person information
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Publication status
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Unpublished
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Publication
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Reference title
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Confirm update of existing submission
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No
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Existing KNA Accession ID
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Sequence Authors
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Sample processing protocol
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Synthetic construct, no biological sample used
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Data processing protocol
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Supplementary information
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Release Protocol?
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Yes
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Topology
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Feature Information
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Sequence source (Backbone)
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SARS-CoV-2, Omicron variant (BA.4/BA.5)
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Sequence source Accession
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Target
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SARS-CoV-2 Omicron Spike Antigen
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Name
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Optimized SARS-CoV-2 Omicron Spike mRNA Antigen
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Purpose
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Research use: mRNA vaccine platform development and evaluation
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Description
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This sequence represents a synthetic codon-optimized mRNA construct encoding the SARS-CoV-2 Omicron spike protein antigen, designed for expression in human cells. The construct was generated as part of a national R&D project aiming to establish novel mRNA vaccine platforms.
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Annotation file format
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None
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Total length
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3812
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Total contigs
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1
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Scaffolds or chromosomes Total length
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Scaffolds or chromosomes Total contigs
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| File Name | Size | Type | Published | Download | |
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| Synthetic construct for SARS-CoV-2 Omicron Spike Antigen using SARS-CoV-2, Omicron variant (BA.4/BA.5), sequence.fasta | 4,081 4,081 | fasta | 2025-08-22 |