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Chemical substance (11,845) Bioassay (10,901) Profiling (3,666)

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전체 선택	Prefix	BioProject	BioProject 명	BioProject 설명	DB type	화합물 ID	약물개발단계	표적 명	Uniprot ID	적용 질환	적용 질환 ID	Disease DB	대조약물 명	공개 일자	데이터 유형	세부 실험 항목	실험 명칭	실험 방법	assay 시료	입력 방식	개념	관계	단위	수치	대조약물 수치	농도
선택	KCP10003041	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4469302	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003042	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4578865	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003043	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4530008	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	26	보고되지 않음	0
선택	KCP10003044	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vivo)	in vivo assay	Oral bioavailability in rat at 5 mg/kg	Administer the test compound to rats at 5 mg/kg via oral gavage (PO) alongside an intravenous (IV) control group, collecting blood samples at serial time points. Quantify plasma drug concentrations using LC-MS/MS, construct concentration-time curves, and calculate absolute oral bioavailability as the ratio of dose-normalized area under the curve	rat	해당사항 없음	Oral bioavailability	=	%	56	보고되지 않음	5 직접입력
선택	KCP10003045	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4572255	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	=	nM	6400	보고되지 않음	0
선택	KCP10003046	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4545243	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	=	nM	7300	보고되지 않음	0
선택	KCP10003047	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4554138	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	78	보고되지 않음	0
선택	KCP10003048	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability	Seed NIH/3T3 cells in a multi-well plate, allow them to attach overnight, and expose them to varying concentrations of the test compound for 24–72 hours.Measure remaining cell viability using a standard cytotoxic assay (e.g., MTT, WST-1, or CellTiter-Glo) and calculate the percentage of cytotoxicity or IC50 relative to untreated controls.	NIH3T3	multiple concentrations	IC50	=	nM	65600	보고되지 않음	0
선택	KCP10003049	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4451470	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	1	보고되지 않음	0
선택	KCP10003050	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4452847	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	1	보고되지 않음	0
선택	KCP10003051	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against human HFL1 cells assessed as reduction in cell viability	Seed HFL1 human lung fibroblast cells in a multi-well plate, allow them to attach overnight, and expose them to varying concentrations of the test compound for 24–72 hours. Measure cell viability using a standard assay (e.g., WST-1, MTT, or CellTiter-Glo) and calculate the percentage of cytotoxicity or viability relative to untreated controls.	HFL1	multiple concentrations	IC50	=	nM	15600	보고되지 않음	0
선택	KCP10003052	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against mouse L929 cells assessed as reduction in cell viability	Seed mouse 929 cells in a multi-well plate, allow them to attach overnight, and expose them to varying concentrations of the test compound for 24–72 hours.Measure remaining cell viability using a standard cytotoxic assay (e.g., MTT, WST-1, or CellTiter-Glo) and calculate the percentage of cytotoxicity or IC50 relative to untreated controls.	L929	multiple concentrations	IC50	=	nM	15800	보고되지 않음	0
선택	KCP10003053	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4460922	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003054	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4444752	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003055	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4471536	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	33	보고되지 않음	0
선택	KCP10003056	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4455226	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vitro)	Selectivity	Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for MERS-CoV/KOR/KNIH/002_05_2015 infected in African green monkey Vero cells expressing viral spike protein	Determine compound cytotoxicity (CC50) on uninfected Vero cells and antiviral activity (IC50) on MERS-CoV-infected Vero cells using standard viability assays.Divide the CC50 value by the IC50 value (SI) to evaluate the compound's therapeutic window and viral selectivity.	Vero	해당사항 없음	Ratio CC50/IC50	=	해당사항 없음	1	보고되지 않음	0
선택	KCP10003057	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vivo)	in vivo assay	Half life in rat at 2 mg/kg, iv	Administer the test compound orally (p.o.) to rats at a dose of 2 mg/kg, and collect serial blood samples at designated time points. Quantify plasma drug concentrations using LC-MS/MS and determine the elimination half-life using non-compartmental pharmacokinetic analysis.	rat	time dependent	half-life	=	hr	4.6	보고되지 않음	2 직접입력
선택	KCP10003058	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4452847	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003059	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4444279	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Toxicity	Cytotoxicity	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability	Cytotoxicity against African green monkey Vero cells is determined by incubating the cells with test compounds and quantifying the reduction in cell viability using a colorimetric or fluorometric assay (such as MTT, CCK-8, or Resazurin) relative to untreated control cells.	Vero	multiple concentrations	Toxicity	>	nM	25000	보고되지 않음	0
선택	KCP10003060	KAP241973	Chemical Data Quality Management and Utilization	Chemical Data Quality Management and Utilization	ChEMBL	CHEMBL4526734	TRL1 (과학적발견)	해당없음	해당 없음	해당 없음	해당 없음	MeSH	보고되지 않음	2026-07-28	Efficacy (in vivo)	in vivo assay	AUC (0 to infinity) in rat at 2 mg/kg, iv	Administer a single 2mg/kg dose of the test compound intravenously to rats and collect blood samples at predefined time intervals up to 24 hours post-dosing. Quantify plasma drug concentrations using LC-MS/MS and calculate AUC0-24h using the linear trapezoidal rule.	rat	single concentration	AUC	=	ng.hr.mL-1	28900	보고되지 않음	2 직접입력

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