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Osteoarthritis (OA) is a common joint disease that causes cartilage damage, pain, and difficulty moving. In this study, we explored whether CRISPR-Cas9 gene editing could slow the progression of OA by targeting three genes involved in the disease: Ch25h, Epas1, and Slc39a8. We compared two delivery methods: adeno-associated viruses (AAVs) and engineered virus-like particles (eVLPs), which deliver gene-editing tools without introducing DNA.