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Exosomes, secreted by most cells that make up tissues, demonstrate cell-specific traits and diversity that are crucial for the regulation of systemic homeostasis through cellular and tissue signaling. In conditions like diabetes, alterations in cellular characteristics are paralleled by changes in the genomic contents within blood exosomes. Our project aims to isolate these exosomes from patients with diabetes and diabetic nephropathy to produce specific genomic data through multi-omics analysis, targeting unique biomarkers for diabetic nephropathy. The project utilizes diabetic and diabetic nephropathy animal models, as well as metabolism-related cell lines, to explore the molecular genetic mechanisms that regulate the formation and release of tissue-specific exosomes.