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The purpose of this project is identification of microRNAs involved in cystogenesis of autosomal dominant polycystic kidney disease (ADPKD) and target genes of these miRNAs via next generation sequencing and bioinformatic analysis. We investigated miRNA-mediated regulatory systems and networks that play an important role during cystogenesis through integrative analysis of miRNA- and RNA-seq using two ADPKD mouse models (conditional Pkd1- or Pkd2-deficient mice).